The Colorado River (Spanish: Río Colorado) is one of the principal rivers (along with the Rio Grande) in the Southwestern United States and in northern Mexico. The 1,450-mile-long (2,330 km) river drains an expansive, arid watershed that encompasses parts of seven U.S. states and two Mexican states. The name Colorado derives from the Spanish language for "colored reddish" due to its heavy silt load. Starting in the central Rocky Mountains of Colorado, it flows generally southwest across the Colorado Plateau and through the Grand Canyon before reaching Lake Mead on the Arizona–Nevada border, where it turns south toward the international border. After entering Mexico, the Colorado approaches the mostly dry Colorado River Delta at the tip of the Gulf of California between Baja California and Sonora.

Known for its dramatic canyons, whitewater rapids, and eleven U.S. National Parks, the Colorado River and its tributaries are a vital source of water for 40 million people. An extensive system of dams, reservoirs, and aqueducts divert almost its entire flow for agricultural irrigation and urban water supply. Its large flow and steep gradient are used to generate hydroelectricity, meeting peaking power demands in much of the Intermountain West. Intensive water consumption has dried up the lower 100 miles (160 km) of the river, which has rarely reached the sea since the 1960s.

Native Americans have inhabited the Colorado River basin for at least 8,000 years. Starting around 1 AD, large agriculture-based societies were established, but a combination of drought and poor land use practices led to their collapse in the 1300s. Their descendants include tribes such as the Puebloans, while others including the Navajo settled in the Colorado Basin after the 1000s. In the 1500s, Spanish explorers began mapping and claiming the watershed, which became part of Mexico upon its independence in 1821. Even after most of the watershed became US territory in 1846, much of the river's course remained unknown. Several expeditions charted the Colorado in the mid-19th century—one of which, led by John Wesley Powell, was the first to run the rapids of the Grand Canyon. Large-scale settlement of the lower basin began in the mid- to late-1800s, with steamboats sailing from the Gulf of California to landings along the river that linked to wagon roads to the interior. Starting in the 1860s, gold and silver strikes drew prospectors to the upper Colorado River basin.

Large-scale river management began in the early 1900s, with major guidelines established in a series of international and US interstate treaties known as the "Law of the River". The US federal government constructed most of the major dams and aqueducts between 1910 and 1970; the largest, Hoover Dam, was completed in 1935. Numerous water projects have also involved state and local governments. With all of their waters fully allocated, both the Colorado and neighboring the Rio Grande are now considered among the most controlled and litigated river systems in the world.

The environmental movement in the American Southwest has opposed the damming and diversion of the Colorado River system due to negative effects on the ecology and natural beauty of the river and its tributaries. During the construction of Glen Canyon Dam (1956–66), environmental organizations vowed to block any further development of the river, and a number of later dam and aqueduct proposals were defeated by citizen opposition. Since 2000, extended drought has conflicted with increasing demands for Colorado River water, and the level of human development and control of the river continues to generate controversy.

In April 2023 as the river shrinks, the Biden administration is getting ready to impose, for the first time, reductions in water supplies to states. The plan would cut the water delivered to California, Arizona and Nevada by as much as one-quarter, and the reduction would be divided evenly across all the states.